Povidone, commonly known as polyvinylpyrrolidone (PVP), is a synthetic, water-soluble polymer that has gained broad acceptance as a pharmaceutical excipient due to its exceptional versatility and safety profile. The polymer is produced by polymerization of N-vinylpyrrolidone, resulting in a material with excellent solubility in both aqueous and organic media. This dual solubility property makes povidone particularly valuable in pharmaceutical development, where it serves as a binder, solubilizer, stabilizer, film-forming agent, and dispersant. In addition, its physiologically inert nature, combined with chemical stability and compatibility with a wide range of active pharmaceutical ingredients (APIs), ensures reliable performance across multiple dosage forms.
Beyond pharmaceuticals, povidone has also been used in biomedical fields as a plasma volume expander and in wound care formulations due to its biocompatibility and low toxicity. Its proven safety record and regulatory approval across major international pharmacopeias make it a trusted choice for formulators worldwide.
Our Products
Our povidone products are designed to meet the diverse needs of pharmaceutical manufacturers. With multiple grades available, they provide flexibility for different formulation requirements, ranging from solubility enhancement and film-forming to binding and controlled release.
| Catalog | Povidone Grade | K-value Range | Molecular Weight (Mw) | Main Applications |
|---|
| PI-PV900 | K12 | 10.2-13.8 | 3000-7000 | Solubilizer, dispersant, crystallization inhibitor for liquid formulations |
| PI-PV901 | K15 | 12.75-17.25 | 8000-12000 |
| PI-PV902 | K17 | 15.3-18.36 | 10000-16000 |
| PI-PV903 | K25 | 22.5-27.0 | 30000-40000 | Binder, film-former, solubilizer, suspension stabilizer and dispersant in solid and liquid dosage forms |
| PI-PV904 | K30 | 27-32.4 | 45000-58,000 |
| PI-PV905 | K60 | 5 -64.8 | 270000-400000 | Binder, thickener, suspension stabilizer in various formulations |
| PI-PV906 | K90 | 81-97.2 | 1000000-1500000 |
Basic Information
- Pharmacopoeia Name: Povidone
- INCI Name: PVP
- CAS No.: 9003-39-8
- Appearance: White to off-white free-flowing powder
- Properties: Non-toxic, non-irritant, hygroscopic, highly soluble in water and many organic solvents; excellent film-forming, binding, solubilizing, and stabilizing properties.
* The K-value is derived from the viscosity of a 1% aqueous solution and further correlated with the average molecular weight by the Mark-Houwink equation.
All our povidone products meet the standards of major international pharmacopoeias, including USP/NF, EP, JP, and BP, ensuring consistent quality, safety, and regulatory compliance for pharmaceutical manufacturers worldwide.
Functional Roles of Our Povidone in Pharmaceutical Formulations
Our povidone products are valued for its multifunctionality, offering a wide range of application benefits in pharmaceutical formulations:
| Application | Application Characteristics in Formulations |
|---|
| Binder | - Preferred binding agent for solid dosage forms (wet/dry granulation, direct compression, fluid-bed granulation).
- Enhances tablet compressibility, hardness, and drug release.
- Suitable for water-sensitive and poorly soluble drugs.
|
| Solubilizer | Improves solubility and bioavailability of poorly water-soluble drugs through complex formation. |
| Dispersant / Co-grinding Agent | - Used as carrier in solid dispersions.
- Forms amorphous dispersions with poorly soluble drugs via co-precipitation or co-grinding.
|
| Stabilizer of Active Ingredients | - Forms amorphous molecular dispersions with drugs, enhancing stability and reducing degradation.
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| Suspension Stabilizer | - Prevents sedimentation in oral and liquid suspensions, ensuring uniform dosage.
|
| Film-former in Coatings | - Acts as coating aid, pore-former, and pigment dispersant.
- Improves adhesion, coating flexibility, and color uniformity.
|
| Crystallization Inhibitor / Thickener | - Prevents precipitation in solutions, regulates viscosity and improves solubility and stability of liquid formulations.
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| Pore-former in Controlled Release | - Creates water-soluble channels in sustained-release and taste-masked dosage forms, adjusting dissolution rate.
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Povidone (PVP) is a multifunctional pharmaceutical excipient that plays an essential role in modern drug development and formulation. Our povidone products, available in various K-values and compliant with international pharmacopoeial standards, provide reliable performance for pharmaceutical companies worldwide. Whether used in solid, liquid, or topical dosage forms, our povidone supports the development of effective, stable, and patient-friendly medicines.
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