Voglibose belongs to a class of competitive alpha-glucosidase inhibitors. It is used for lowering post-prandial blood glucose levels in people with diabetes mellitus. Alpha-glucosidase inhibitors are oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of complex carbohydrates (such as starch). Complex carbohydrates are normally converted into simple sugars (monosaccharides) which can be absorbed through the intestine. Hence, alpha-glucosidase inhibitors reduce the impact of complex carbohydrates on blood sugar.
Product Details
Molecular Formula
C10H21NO7
Molecular Weight
267.28
Standard
IP
Mechanism Of Action
Alpha-glucosidase inhibitors are saccharides that act as competitive inhibitors of enzymes needed to digest carbohydrates: specifically alpha-glucosidase enzymes in the brush border of the small intestines. The membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the small intestine. Voglibose delays the absorption as well as digestion of dietary polysaccharides by reversibly inhibiting carbohydrate digestive enzymes like sucrose, maltose, zomaltase, etc. Valigobose may also facilitate mobilisotary α endogenous glycogen-like peptide 1 (GLP-1), which has an inhibitory action on glycogen, thus lowering fasting glucose levels too. Voglibose treatment has resulted in an increased release of GLP-1, which is an insulinotropic hormone and it has also increased the release of GLP-1, which is known to enhance insulin secretion and insulin sensitivity. Voglibose has no inhibitory activity against lactase and so, it does not cause lactose intolerance and diarrhea. It also has also shown an additive effect with other Oral Hypoglycaemic Agents (OHAs) like sulfonylurea. It also diminishes the insulinotropic and weight-increasing effects of sulfonylureas.
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