Sulfadimethoxine sodium

Mosconi N, et al. Polyhedron, 2021, 195, 114965.

Sulfadimethoxine sodium (NaSDM) was utilized as a key ligand in the synthesis of silver(I) complexes exhibiting antifungal activity. Three complexes-AgSDM, AgSDM-SCN, and AgSDM-phen-were synthesized via solution-based coordination with AgNO₃, under light-protected conditions. For AgSDM, AgNO₃ was added dropwise to NaSDM solution, forming a white suspension, which was filtered and dried. AgSDM-SCN involved sequential addition of KSCN after AgNO₃, yielding a stable white precipitate. For AgSDM-phen, o-phenanthroline dissolved in ethanol was added to a pre-formed AgSDM suspension. All products were isolated by vacuum filtration and dried in the dark. Structural characterization was confirmed by elemental analysis, FTIR, and NMR. Antifungal testing revealed moderate activity against Candida albicans, C. tropicalis, and Cryptococcus neoformans, whereas NaSDM alone showed no activity. Lipophilicity assessments indicated enhanced membrane permeability. Notably, AgSDM and AgSDM-SCN displayed no cytotoxic or genotoxic effects in the Allium cepa assay, supporting their potential for pharmaceutical development.