Sacubitril

Name: Sacubitril
SKU: PI149709626
Rating: 5 (1 reviews)

Catalog NumberPI149709626

CAS Number149709-62-6

CategoryCardiovascular Drugs

Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.

Product Details

Synonyms	AHU-377; (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester
Purity	98.0%
Molecular Formula	C24H29NO5
Molecular Weight	411.49
Key Use	Anti-heart failure
Appearance	White or off white powder

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Other Identifiers

IUPAC Name	4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid
InChI	InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1
InChI Key	PYNXFZCZUAOOQC-UTKZUKDTSA-N
Canonical SMILES	CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O
EC Number	810-278-2

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