Tivozanib

Name: Tivozanib
SKU: PI475108180
Rating: 5 (1 reviews)

Cat. No.: PI475108180

Product Details Other Identifiers Computed Properties

CAS	475108-18-0
Synonyms	1-(2-Chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-3-(5-methylisoxazol-3-yl)urea
Purity	min. 98%
Molecular Formula	C22H19ClN4O5
Molecular Weight	454.86
Molar Refractivity	120.0

Pubchem ID	9911830
InChI Key	SPMVMDHWKHCIDT-UHFFFAOYSA-N
MDL Number	MFCD15146788

Hydrogen Bond Donor Count	2.0
Hydrogen Bond Acceptor Count	7.0
Rotatable Bond Count	8
Topological Polar Surface Area	107.74 Å²
Heavy Atom Count	32
Aromatic Heavy Atoms Number	21
Fraction Csp3	0.14
Log Po/w (iLOGP)	3.67
Log Po/w (XLOGP3)	4.03
Log Po/w (WLOGP)	5.26
Log Po/w (MLOGP)	2.11
Log Po/w (SILICOS-IT)	3.5
Consensus Log Po/w	3.71
GI Absorption	High
BBB Permeant	No
P-gp Substrate	No
CYP1A2Inhibitor	Yes
CYP2C19Inhibitor	Yes
CYP2C9Inhibitor	Yes
CYP2D6Inhibitor	Yes
CYP3A4Inhibitor	Yes
Log Kp (Skin Permeation)	-6.21 cm/s
Lipinski	0.0
Ghose	None
Veber	0.0
Egan	0.0
Muegge	0.0
Bioavailability Score	0.55
PAINS	0.0 alert
Brenk	0.0 alert
Leadlikeness	3.0
Synthetic Accessibility	3.58

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