2-Amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethanone

Name: 2-Amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethanone
SKU: PI1261114015
Rating: 5 (1 reviews)

Cat. No.: PI1261114015

Product Details Other Identifiers Computed Properties

CAS	1261114-01-5
Synonyms	GNF179
Purity	98%
Molecular Formula	C22H23ClFN5O
Molecular Weight	427.90
Molar Refractivity	119.93

Pubchem ID	58178960
InChI Key	KFSKTWYDIHJITF-UHFFFAOYSA-N
MDL Number	MFCD28167758

Aromatic Heavy Atoms Number	17
BBB Permeant	Yes
Bioavailability Score	0.55
Brenk	0.0 alert
Consensus Log Po/w	3.26
CYP1A2Inhibitor	Yes
CYP2C19Inhibitor	Yes
CYP2C9Inhibitor	No
CYP2D6Inhibitor	Yes
CYP3A4Inhibitor	Yes
Egan	0.0
Fraction Csp3	0.27
Ghose	None
GI Absorption	High
Heavy Atom Count	30
Hydrogen Bond Acceptor Count	4.0
Hydrogen Bond Donor Count	2.0
Leadlikeness	1.0
Lipinski	0.0
Log Kp (Skin Permeation)	-6.78 cm/s
Log Po/w (iLOGP)	3.12
Log Po/w (MLOGP)	2.88
Log Po/w (SILICOS-IT)	3.25
Log Po/w (WLOGP)	4.05
Log Po/w (XLOGP3)	3.0
Muegge	0.0
PAINS	0.0 alert
P-gp Substrate	Yes
Rotatable Bond Count	5
Synthetic Accessibility	3.7
Topological Polar Surface Area	76.18 Å²
Veber	0.0

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